Founded in October 1963, Akatsi Training College opened her doors to the first batch of forty-two (42) all-male students. Apart from the first Principal, the late Mr. Seth K. Ahiable, there were three other tutors constituting the teaching staff. The three men who helped to lay the academic foundations of the College with the Principal were Messrs Cletus A. Akorlie (as Senior House Master), Michael Adodo Gaba, and Leo M. Adotey. According to the records, by October 28, 1963, the initial intake of 42 had risen to 56 students.

The idea of establishing a Teacher Training College at Akatsi was the brainchild of the then Member of Parliament for Avenor (as the constituency was then known), Hon. M.K. Maglo and the then District Commissioner (DC), Mr. John G. Bedzo. Torgbui Letsa Korba II, Dufia of Akatsi, who willingly provided the tract of land which currently stands the structures of the College.

Akatsico had seen very humble beginnings when she was housed in the deserted wooden and corrugated roofing sheet structures of Taylor Woodrow Construction Company that built the Accra-Aflao Road (also known as John Miller Road, named after the firm’s Chief Engineer). A number of these structures still stand today albeit in very sorry states of dilapidation. The first Principal’s office had survived the many years of termite attacks and defiantly stands as a museum piece monument beside the College resource centre.

Driven by the echoes and reverberations of the national needs for education, the founding fathers chose the motto: HEAD, HEART, HAND for the College. The choice of this motto is significantly in consonance with the College’s mission of giving its trainees a holistic education that builds the individual intellectually, physically and in the affective domain.

The College became a co-educational institution in 1967, four years after its inception and the first batch of female students, numbering twenty-four, were enrolled.

In 2004/2005 academic year, the status of the College changed from that of a Certificate awarding Institution to a Diploma awarding institution hence the change in name of the College from Akatsi Training College to Akatsi College of Education.